BIOL 205 Lecture Notes - Hox Gene, In Situ Hybridization, Antennapedia

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A cell has to define what is up, down, left, right (anterior, posterior, ventral, dorsal) ex: moths: each cell on wing is programmed to be different colour. Have to be a system in place that tells cell where it needs to go and once it gets there it needs to be programmed to generate unique transcription to produce a particular colour. Transplantation experiments confirmed that organizing activities play a role in long term pattern formation in higher organisms. Little stubs that were once wings (lost through evolution) now used for balancing. Creates a drosophila embryo that has little hairs on it: looks like a hedgehog. Hox genes regulate the identity of body parts: two gene complexes control segment identity, order on chromosome corresponds to order of body regions from head to tail. Hox genes are expressed in spatially restricted domains. Final expression of hox genes in adult depends on controlled of their expression early in embryogenesis.

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