BIOL 102 Lecture Notes - Lecture 14: Inner Mitochondrial Membrane, Acetyl-Coa, Mitochondrial Matrix

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Cellular respiration: how living cells obtain energy from organic molecules: goal: make energy intermediates (atp, nadh) Glycolysis: (3 phases: energy investment: (cytosol) phosphorylation of sugar increases pe o. Output: fructose 1,6, biphosphate o: cleavage: (cytosol) 6 carbon molecule broken down into 2g3p iii. G3p broken down into 2 pyruvate molecules o. Prepare for citric acid cycle: input: (broken down by) pyruvate dehydrogenage, acetyl group (attached to coa, output: 1 co2 per pyruvate, 1 nadh per pyruvate, regulation: pdh, allosteric inhibitor/activation. Many e- carriers, high energy by products regenerate oxaloacetate to start cycle: input: oxaloacetate (attaches to acetyle from acetyl coa forms citrate, output: (per acetyl): 2co2, 1atp, 3nadh, 1fadh2, regulation: pdh. Pathway, not regenerated: input: nadh, fadhs (contains high energy e-), o2. Movement of nadh o2 = negative free energy change. Sent to inner mitochondrial matrix to create proton gradient: some energy used. Through e- transport chain establish electrochemical gradient: ubiquinone: not a protein.

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