BCHM 310 Lecture Notes - Lecture 18: Amyloid Precursor Protein, Disulfide, Amyloid
22 Dec 2018
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Illustrates the concept that 1 structure dictates 3 structure (ribnucleotide 100 aa) Proteins fold into a small # of low energy conformations: these are virtually identical but loop regions may be diff. Basically a well with lowest e conformations at the bottom where there is the most folding. Proteins being to fold as they exit the ribosome: cell provides unqiue enviro that assists in protein folding. Result of amyloids accumulating in brain: amyloid precursor protein (app, n term region is 42 aa and gets cleaved off oligomerizes extended b- structure amyloid fibrils. 1 structure: has high proportion of charged, polar uncharged aa and pro/gly. Considerations: lacks hydrophobic core: no apparent stable 2 structure think pro function: allows for adaptability and functional promiscuity.
