BCHM 102 Lecture Notes - Lecture 12: Heinz Body, Vicia Faba, Phagocytosis
2 Dec 2016
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Document Summary
Describe the roll of the pentose phosphate pathway in production of ribose 5-p and nadph. Compare and contrast the roles of nadh and nadph: highlight the importance of nadph with examples of activity in: reductive biosynthesis, reduction of hydrogen peroxide and destruction of bacteria. Connect hereditary deficiencies of g6pf with the associated pathology of hemolytic anemia. Involves 2 irreversible oxidative reactions and a series of reversible sugar phosphate interconversions. For every substrate molecule 1 co2, and 2 reduced nadph are produced. Provides: majority of nadph supply (biochemical reductant, ribose 5-phosphate for nucleotide synthesis. Nadp+, like nad+, is reduced by the addition of 2e- and an h+ to form nadph. Differs only in the presence of an extra phosphate on nadp. Little to do with redox activity, but is recognized by substrate binding sites of enzymes: mechanism for separation of catabolic and synthetic pathways, nadp is not used for redox reactions (?)
