BIOL 318 Lecture Notes - Lecture 23: Transplant Rejection, Anaphylaxis, Chemokine
30 Nov 2018
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Ige: binds to fc receptors on plasma membranes of mast cells and blood basophils. Inflammatory response: mechanism of type i hypersensitivity reaction, release of vasoactive amines (ex. histamine) by mast cells, contraction of intestinal and bronchial smooth muscles: constricts bronchial passages. Injection of allergen into (intradermal) or onto (epicutaneous or prick test) the skin of a sensitized individual local anaphylactic reaction. Igg acts as blocking ab to compete with fixed ige on mast cell for allergen: hygiene hypothesis: early microbial infections might be important in biasing our immune systems toward producing th1 helper t cells in response to environment. Involved in: rejection of transplanted organs, granulomatous reaction in chronic infection, tuberculin skin test, contact-dermatitis reactions, soaps, lotions, plant poisons itchy rash. Thursday november 29th 2018: poison ivy: oil in sap causes reaction in susceptible individuals. Initial contact with ag results in production and sensitization of th1 cells.
