PSYCH 2NF3 Lecture Notes - Lecture 1: Neuroglia, Longitudinal Study, Bipolar Disorder
16 Jan 2018
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Document Summary
The changing brain: axon sprouting, dendritic branching and neurogenesis, glial changes and angiogenesis, sheets can get thicker, thinner, adapting. Image intensity is describing the underlying tissue composition: signal in certain imaging protocols is spatially correlated with myelin, brighter areas are primary sensory areas. T1- weighted imaging: signal analysis requires removal of bias fields, we used a ratio of t1 w/pd image- known to report myelin content. Aging: myelin should increase into middle adulthood and tapers due to neurodegeneration. Inflates then deflates the brain to accurately registrate: mapping each brain in the same spot. Healthy population: decreasing pattern of myelin towards cortex. Validating frontal map with histology: mfg highly myelinated. Depths: peak of signal trajectory is similar across cortical depths, visual areas peak earlier, motor areas peak later (latest) Bipolar disorder: considered developmental, does intracortical signal change over time course, myelin deficits in the brain to begin with, decreases in cortical oligodendrocytes, glial cells.
