PSYCH 2AP3 Lecture Notes - Lecture 35: Adrenocorticotropic Hormone, Etiology, Neuropeptide

• School: McMaster University
• Department: Psychology
• Course: PSYCH 2AP3
• Professor: Geoffrey Hall

Document Summary

Lomoar cpsd| 2151316: mao-i inhibit the breakdown of neurotransmitters. Antidepressants and ect: reduce beta adrenergic receptors; increase serotonergic response, beta-adrenergic receptors (relaxation, inhibition) Lithium: stabilizes serotonergic activity (mechanism of action unclear) Dopamine: precursor: l-dopa, enhances effect of mao inhibitors may lead to hypomania in bd. Metabolite: hv a (homovanillic acid: not lower in csf of depressed patients o lower in motor retardation. Norepinephrine: metabolite: mhpg (3-mehtozy, 4-hydrozyphenylglycol, lower levels of urinary mhpg in depression than controls, especially true in bipolar patients. Serotonin (5-ht: precursor: tryptophan, may be antidepressant in mild cases, metabolite: 5-hiaa (5-hydroxyindoleacetic acid, small majority of studies find lower csf (cerebral spinal fluid) levels of. 5-hiaa in depression: low csf levels of 5-hiaa in aggression, impulsivity, suicide. Lowe levels of serotonin allow other levels of neurotransmitters fluctuate widely, and those neurotransmitter levels are responsible in depression. Serotonin regulates neural activity: dopamine and norepinephrine. Reduced regulation = wider activity changes, manic or depression lomoar cpsd| 2151316.