PSYCH 2AP3 Lecture Notes - Lecture 36: Inverse Relation, Comorbidity, Xerostomia
21 Sep 2020
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Lomoar cpsd| 2151316: ssris, mao inhibitors, omega-3 acids: good as antidepressants when no comorbid anxiety, ketamine: at lower than anesthesia dose, rapid relief of depression ( special k ) Primarily used as pediatric anesthetic, and in pain management. At sub-anesthetic doses, ~70% of treatment-resistant depressed patients respond within hours. Side effects usually mild, but may cause acute psychotic symptoms (hallucinations) in some. A drug of abuse as special k . Ndma glutamate receptor antagonist, blocks or works on glutamate transmission. Zanos et al (2016: ketamine has 2 versions: s-ketamine and r-ketamine, s-ketamine better blocker of nmda receptor, but r-ketamine has stronger antidepressant effect, metabolites of r- and s-ketamine (2r, 6r)-hydroxynorketamine (hnk), and (2s, 6s)- hnk have antidepressant properties; 2r, 6r more than 2s, 6s: antidepressant action seems to involve quick and continued activation of. 1 in every 100 people will have schizophrenia, 1 in 10 of those people will end their lives. Was adopted in england: normal baby in infancy.
