NURSING 3PA2 Lecture Notes - Lecture 20: Brain-Derived Neurotrophic Factor, Tricyclic Antidepressant, Insomnia
10 Apr 2018
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Treatment: antidepressant drugs: ssris, maois, tcas, novel or dual antidepressant drugs. It is believed that antidepressant treatments may increase synaptic sprouting or rewiring of connections, which are disregulated at the synapse. If you think about the phrase if you don"t use it, you lose it , this can also apply to what happens at the synapse. Without treatment for depression, synaptic pruning means that when connections between nerve cells are not used, nerve cells atrophy and volume decreases. With treatment, connections are once again used and formed, and brain volume in the areas implicated in depression increase. Their clinical antidepressive effects occur only after chronic administration of days to weeks. In general, these drugs normalize levels of serotonin, dopamine, and norepinephrine in the brain, and thus, their neurotransmission at the synapse. lomoar cpsd|2151316. Antidepressants also increase levels of bdnf, and affect synaptic plasticity by increasing the activity of neurotransmitters in the synapse and nerve cell volume.
