MUSIC 1A03 Lecture Notes - Lecture 3: Progesterone Receptor, Aldosterone, Cortisol
Document Summary
Typically, binding of water soluble hormones to cell surface receptors leads to the manufacture of second messengers (dag or ip3) which alter cell function. Water soluble endocrine hormones that activate g proteins include. Must bind to receptor to exert the effect inside the cell. Receptor can be associated with a g protein or membrane spanning enzyme. Some water soluble hormones bind to extracellular receptors that activate protein kinases directly (no 2nd messengers) Move through the bloodstream bound to a transport protein. These hormones form a complex with their receptor and then bind to dna. As hormones rise, negative feedback brings them back to normal. Rise in progestins has a high effect on the uterine cycle. Hormonal changes during the ovarian and uterine cycles. Arises from the action of aromatase on testosterone. During menopause, predominant circulating form of estrogen. Conserved form of estrogen in fatty tissues.
