MEDRADSC 2X03 Lecture Notes - Lecture 7: G1 Phase, Spinal Cord, S Phase
17 Mar 2018
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The cells can basically freeze disturbance in the cell cycle activity= division delay: division delay, g1 preparation state. Lethal damage: apoptotic death, mitotic death. Non-lethal damage--- single strand break: reparable, non-reparable. Time required to complete one cell cycle. Varian in tc for mammalian cells is mainly due to difference of. G1 phase: mitosis completed in approx 1 hour, dna synthesis (s phase) within 15 hr. Not all cycle has the same cell cycle time. Most cells r the same except the g1 phase. Table 4. 1 shows you the difference between the g1 phases of different cells. All the cells in the body are not all going through mitoss at the same time. In vitro cells: normally asynchronous, synchronized population can be produced in lab. Cyclins are used as check point genes. They decide when we should leave g1 and go into s and when we should leave s and go into g2.
