MEDRADSC 1B03 Lecture Notes - Lecture 6: Systemic Lupus Erythematosus, Anti-Nuclear Antibody, Autoimmune Disease

• School: McMaster University
• Department: Medical Radiation Sciences
• Course: MEDRADSC 1B03
• Professor: sandra charbonneau

Document Summary

Both b and t cells involved in this. As your age, your immune system wears and tears. A chronic issue can create an autoantibody response. Production of antibodies (autoantibody) which attacks individual"s own tissue. Leads to inflammation and necrosis of tissue. Immune complex: something that happens with antigen and antibody connected. Autoimmune disease: chronic inflammatory disease affecting many systems. Hard to narrow down since it affects many systems (magic number is four) Pathophysiology: +++ circulating autoantibodies, immune complex deposits throughout body in connective tissue> inflammation and necrosis. Vasculitis (inflammation of vessels, causing vasoconstriction)> ischemia> more inflammation> necrosis. Blood test will see if there are a lot of autoantibodies. Complement- chain of reactions that happens when immune complexes are deposited in connective tissue. There are 3 general results: cell lysis (killing of cells), area of deposition can be tagged and wbc phagocytose the area, and increase inflammatory response (lead to more cell death).