LIFESCI 3B03 Lecture Notes - Dementia, Attention Deficit Hyperactivity Disorder, Circumventricular Organs
19 Feb 2013
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Reactive: caused by external factors, no biological basis a. Secondary depression is when you are depressed because you have another illness like schizophrenia. In a double blind experiment with placebo and fluoxetine, both groups showed equal improvement in 6 weeks. Pet scans showed increased activity in the pfc, pmc, anterior and posterior cingulate, posterior insula. And a decrease in subgenual cingulate, hypothalamus, parahippocampus and thalamus. But in fluoxetine only the brain stem was increased and a decrease in hippocampal and striatal activity. Fluoxetine effects larger areas and causes stronger pet signals vs. placebo. Fluoxetine works in a bottom-up cascade meaning it effects the cortex through the brain stem. Where as cbt or placebo works in top-down manner meaning it"s the cortex is effecting the lower brain areas. Sris are used to treat depression, which increase the amount of serotonin available at a synaptic cleft. Which increases the synapses of serotonin, which supports the bottom-up cascade theory.
