KINESIOL 2G03 Lecture Notes - Lecture 28: Dentate Gyrus, Henry Molaison, Cardiovascular Fitness
2 Apr 2016
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Lecture 28: smart jocks: your brain on exercise. Brains vs. brawns in not a true dichotomy. Cardiovascular fitness is associated with higher intelligence: smart jocks. Increase in hippocampal neurogenesis in young and older animals: increase in new cells by proliferation. Increase in brain derived neurotropic factor (bdnf: no accumulation over time, upregulation after 3 days of exercise, helps promote new cell growth in hippocampus, more mrna expression with farther distances run. Occurs in the dentate gyrus of the hippocampus: cells migrate and integrate into new network, maturation takes time. Exercise promotes neurogenesis but enrichment promotes cell survival: ex, mice who ran on treadmills vs. puzzles, environment is critical for integration into new network. Neural changes and their effect on cognitive functioning. Patient hm lost ability to form new long term memories after hippocampi lobectomy: no longer generating new cells to form new memories. Memories are stored in specific brain cells in the hippocampus.
