HTHSCI 1DT3 Lecture Notes - Lecture 19: Vasculitis, Anticoagulant, Acute Respiratory Distress Syndrome
13 Aug 2020
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Document Summary
Mod. 1-17 pathobiology of novel treatments for idiopathic pulmonary fibrosis 3. Displays a classic basilar, peripheral and patchy pattern of reticular (netlike) opacities, because lung is pulled apart from stiff fibrous tissues. Occur in absence of extensive ground-glass opacities (indices of inflammation). Fibroblastic loci with myofibroblast over-producing collagen and ecm. Loss of alveoli air-spaces because fibrosis causes architectural remodelling: specific combinations of hrct and surgical lung biopsy pattern. It is chronic and progressive, where patients only had a median survival of 2. 8 to 4. 2 years and they usually die due to respiratory failure. Relatively stable after symptoms, but there will be sudden deterioration in lung function. Infection (due to the lost of type i pneumocytes) could cause more subsequent decline of lung function and end up with respiratory failure. More than 50% have clubbed fingers: complications of ipf, respiratory failure, pulmonary hypertension due to the change in alveoli capillary bed and blood shunting.
