HISTORY 1M03 Lecture Notes - Lecture 17: Thioether, Amphoterism, Imidazole
25 Apr 2021
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Learning outcomes: learn and remember the 20 amino acid structures, understand how a peptide bond is created, analyze different polypeptide chains. Backbone is everything except the unique r groups. All amino acids are chiral (can"t be superimposed on its mirror image) except for glycine (has h as r group) We will only deal with the l-amino acid = an amino acid that rotates plane polarized light to the left. Amino acids link together to form a polypeptide through a peptide bond. Oligopeptide = few amino acids joined together. Polypeptide = many amino acids joined together. Peptide bond formed by nucleophilic addition-elimination reaction between carboxyl and amino groups of adjacent amino acids. Nucleophilic attack occurs (the amino group attacks the carbon) (addition) The peptide bond is planar (doesn"t rotate much) because of resonance (forms double bond) Multisubunit proteins = proteins that have 2 or more polypeptides non-covalently bonded. Oligomeric protein = proteins that have at least 2 polypeptides that are identical.
