CHEM 2OA3 Lecture Notes - Lecture 2: Crystallization, Miscibility, Acetic Anhydride
20 Jun 2016
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Reaction: to change functional group there must be a reaction, reaction mixtures will then contain. Separation: almost all cases, there is separation of chemical compounds to obtain pure product. Separation science has expanded into biochemistry for proteins, nucleic acids etc. We will be using melting points of material and comparing it with known melting points for compound identification (carboxylic acid) Natural sources (yew tree for taxol etc. ) Separation science used for example in the fermentation of penicillium, penicillin and cell organs need to be separated and purififed. 50% of pharmaceuticals are from a lead isolated in nature: aspirin: a classical case. Salicylic acid present in the bark of yew trees is the active ingredient in aspirin. Within in all the tree compounds, salicylic acid needs to be separated. Aromatic ring structure, phenol group, carboxylic acid. Chemical reaction converts it into a semi-synthetic drug known as acetylsalicylic acid. Alcohol is converted into an ester with acetic anhydride.
