BIOLOGY 3UU3 Lecture Notes - Lecture 9: Mutation, Superoxide Dismutase, Superoxide
4 Apr 2016
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Document Summary
Tissue difereniaion is dependent on epigeneic histone modiicaions. Most involved histone structural changes rather than genes. Main determinants of informaion appears to be regulatory (a lot of info in the genome thought to be. Genes will have hypersensiive sites where transcripion takes place. Tissue difereniaion use of histone modiicaions useless, it is being used in diferent kinds of specialized issue) Histone structure regulated by acetylaion, acetyltransferases (add acetyls to histones, allow dna to be transcribed, deacetylases bring genes in heterochromain, methylaion associated with methyltransferases afect histone, as well as on genome) Maternal efects on lizards change size of the eggs, change acivity. Ability to imprint genome across generaions, transmit histone structure. Used to think maternal ones were the only important ones. Sperm are so small, some don"t even have mitochondria (just have atp), how long they swim and how much determined by how much atp is packed into the cell. Sill capable of transmiing an altered histone structure.
