BIOLOGY 3UU3 Lecture Notes - Lecture 2: Sirolimus, Insulin Resistance, Sexual Reproduction
12 Apr 2017
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Document Summary
Functions may compete for resources or act antagonistically: incompatible to various degrees. Fundamental tradeoff between production (growth/reproduction) vs stress resistance (in bad environments: production resistance tradeoff, stress resistance tends to slow aging while high production accelerates it. Conservation of mouse and human genomes: allows study of the same pathways that impact aging in humans in animal models, high conservation in genes, but degree of expression varies strongly. Homeostasis: maintenance of normal internal stability: coordinated regulation to maintain evolved set points in the face of perturbations. Principle of allocation: given level of available resources, key elements of fitness are traded off. All functions face potential constraints: energy allocated to one function may reduce that available to others tradeoff. Maximizing synergy among functions as minimizing interference: physical separation or temporal separation. Homeorhesis: regulation of dynamic physiological processes to maintain a targeted trajectory over time.
