BIOLOGY 3UU3 Lecture Notes - Lecture 1: Vasoactive Intestinal Peptide, Sleep Deprivation, Insulin Resistance
26 Sep 2016
School
Department
Course
Professor
Document Summary
Growth hormone axis (gha) and the stress hormone axis (sha) Underlying this theory was his recognition that the pro- inflammatory somatotropin axis (=growth hormone) was counter-balanced by the stress hormone axis (which was anti-inflammatory. Gh secretion occurs in strong pulses in early sleep associated with slow-wave brain waves. Sleep deprivation suppresses gh secretion as it involves activation of the counter- regulatory sha. Insulin-like growth factor (igf-1), liver, doesn"t show strong circadian rhythmicity, 3 binding proteins igfbp) upregulates its activity in early sleep via regulation of igfbps, a second igf protein (igf-2) allows some specialization in gha impacts. Growth hormone releasing hormone (ghrh) may upregulate sleep. Somatostatin (or somatotropin release-inhibiting factor (srif)) appears inhibitory, but may also promote rems at some doses. Sleep deprivation increases mrna for srif and ghrh. Igf-1 and the stomach hormone ghrelin (grl) may also induce sleep. Ghrelin to sleep is complex, appears to stimulate slow wave sleep. Sleep deprivation elevates ghrelin and reduces fat hormone leptin.
