BIOLOGY 3UU3 Lecture Notes - Lecture 4: Sirtuin, Glutathione Disulfide, Insulin Receptor
26 Sep 2016
School
Department
Course
Professor
Document Summary
Oxidative stress and aberrant signalling in aging and cognitive decline. Evidence for an age related increase in oxidative damage and decrease in antioxidant levels. An increase in protein carbonyl levels has been demonstrated for various brain regions including the hippocampus. Age-related memory impairment is correlated with a decrease in brain and plasma. Hypothesis: hypothesize that the decrease in intracellular gsh may be mechanistically related to the age-related decrease in post-absorptive plasma cysteine that has been found in humans between the third and the ninth decade of life. Sirtuin proteins are a family of protein deacetylases, pathways in aging process: certain ones regulate glucose, fat metabolism, enhance mt biogen, deactivate tupor suppressor p53. Ampk, increased mt numbers and better motor function. Autophagy and situin expression downreg by insulin cascade, inferred autophagy and sirtuin activity expressed when insulin low so at night post absorptive state (no confirm) Insulin-independent basic activity of insulin r sig pathway is weak and subject to redox.
