BIOLOGY 2C03 Lecture Notes - Lecture 3: Canadian English, Chromatin, Karyotype
26 Nov 2016
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We would see both these chromosomes in every cell, male or female. Effect depends on the gene youre looking at. Methylation = on igf2 and on h19 (paternal) Maternal = opposite (silence igf2 due to ctcf, turn on h19). Methylation doesn"t always turn something off, it depends on the gene youre looking at. One cell, has a maternal imprinted and paternal imprinted, have on igf2 active, one h19 allele active. Normal state for mice growth - express just the one igf2. If you have a mutation where both copies of the gene are expressed - mice are larger. Methylase is expressed in germ cells in males, not females. Left hand side of slide 36 - resetting - erasing maternal and paternal taggs and resetting them so that the maternal chromosome is off. Male gametogenesis - males are reset to both chromosomes are methylated and igf2 has the potential to be reset. has the potential to be reset.
