BIOLOGY 1M03 Lecture Notes - Lecture 3: Heterozygote Advantage, Mns Antigen System, Mate Choice

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Four factors that change allele frequencies: natural selection increase/decrease, genetic drift, gene flow (mutation, mutation. Study how factors affect population, 1908 mathematical model to analyze allele frequencies of individuals in a population. Imagines all of gametes grouped into gene pool with same allele frequencies as original. Calculations predict genotype frequencies of the offspring of the population would produce. Holds when 5: no natural selection, no genetic drift, no gene flow (migration, no mutation, no biased mating. Simplest situation: 1 gene, 2 alleles (a1, a2) Frequency of a1 has frequency p & a2 frequency q. P2+2pq+q2 = 1 (only if population is hwe) Example (hwe: a1a1 = 36, a1a2 = 48, a2a2 = 16, p= 0. 36+(0. 5)*0. 48 = 0. 60, q= 0. 40, p = square root p2. Hardy-weinberg principle assumptions: if frequency of alleles in a population are given by p & q, there will be a1a1, a1a2, a2a2, when alleles are tra.

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