BIOLOGY 1M03 Lecture Notes - Lecture 6: Selective Sweep, Haplotype, Lactase
3 Apr 2018
School
Department
Course
Professor
Document Summary
Pottery in north-central europe from 6 kya > milk residues. All 8 genotyped fossil humans from 6 kya in northern europe lack mutant lhp gene for lactase persistence (c-13910 allele) Cause is dairy, effect selection of milk. Directional selection in populations with history if dairying. Selective sweep" allows molecular evidence of this. With a small selective advantage the frequency of the allele can be sweep to prominence within 7000 yrs (300-350 generations) This places lactase persistence evolution within 10,000 yrs allowing detection of a selective sweep. Stored for production of cheese & yogurt (low in lactose) Milk proteins and lactose facilitate absorption of calcium (in lactose persistent people) and milk contains high ca levels. Lactose malabsorption is higher in ,low latitudes, warmer temperatures, or where there is high levels of cattle disease. Barriers of dairying seem to explain patterns of lactose malabsorption.
