BIOLOGY 1M03 Lecture Notes - Lecture 1: Single-Nucleotide Polymorphism, Zygosity, Missense Mutation

• School: McMaster University
• Department: Biology
• Course: BIOLOGY 1M03
• Professor: Lovaye Kajiura

Document Summary

By the end of this tutorial students should be able to: Define and identify synonymous and non-synonymous substitutions. Define and identify different types of mutations. Read the introductory material in this student manual. Read pages 364 368 in the how humans evolved textbook. Review bioskills 3 in the bioskills section at the back of biological. Review the information at the following link: http://www. ncbi. nlm. nih. gov/class/mlacourse/modules/molbioreview/iupac. Mutatio(cid:374)s (cid:396)esult i(cid:374) cha(cid:374)ge to a(cid:374) o(cid:396)ga(cid:374)is(cid:373)"s dna se(cid:395)ue(cid:374)ce. O(cid:373)e nucleotide changes result in a change to the amino acid that is coded for by that particular codon, while others do not. This is possible because of the redundant nature of the nuclear genetic code. Single nucleotide difference between dna sequences a(cid:396)e called si(cid:374)gle (cid:374)ucleotide poly(cid:373)o(cid:396)phis(cid:373)s, o(cid:396) (cid:862) nps(cid:863). As you can see in the table above, changing the third nucleotide in many cases does not result in an amino acid change. Synonymous mutations do not change the amino acid sequence in a protein.