BIOLOGY 1A03 Lecture Notes - Lecture 13: Epigenome, Epigenomics, Methyl Group

• School: McMaster University
• Department: Biology
• Course: BIOLOGY 1A03
• Professor: Alastair Tracey Rosa Da Silva

Document Summary

Some signals can go through membrane (hydrophobic) So, signal binds to receptors outside membrane. Causing a response cascade (signal transduction cascade) Stc can lead to short term and long-term responses in the target cell. A: short term: modify immediate cell processes (ex metabolism, movement) B: long term: modification of gene expression. Dna is in semi wound state to allow for transcription must unwind coil (chromatin fiber) to expose the nucleotides. Not changing nucleotides just adding groups (ex methylation) not changing dna sequence. Essential for normal development, cell differentiation and increasingly being recognized as being involved in human diseases. Genome is inherited, epigenome can be altered. Chemical dna modifications that occur along the genome that change gene activity without altering the dna sequence. Epigenetic processes are essential for normal development, cell differentiation and increasingly being recognized as being involved in human diseases. Influenced by the environment (youth what you eat etc. )