BIOCHEM 2EE3 Lecture Notes - Hydroxyproline, Proline, Hydrogen Bond
17 Mar 2014
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Document Summary
Primary protein structure: amino acid sequence of polypeptide chain: primary structure determines properties of a protein. Ramachandran diagram: b-sheets: stabilized by h-bonds between two parallel backbones, in the parallel sheet, backbones extend in the same direction. , in the antiparallel b-sheet, the backbones extend in opposite directions. Depending on their overall shape, proteins are classi ed as either. Brous or globular: collagen is a brous protein. It is the most abundant vertebrate protein: numerous glycine, proline and hydroxy-proline residues, collagen is a triple-helix protein. Side chains of pro residues in collagen are hydroxylated with the help of enzyme (prolyl hydroxylase) and coenzyme (absorbic acid - vitamin c). Lack of vitamin c results in scurvy - collagen cannot form its bers: superhelical structure of collagen is formed of three collectively twisted polypeptide helices. Tertiary structure: refers to the folding of secondary structure segments.
