BIOCHEM 2EE3 Lecture Notes - Lecture 10: Thioester, Oxaloacetic Acid, Thiamine Pyrophosphate

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21 Apr 2018

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Overview of the breakdown of glucose to co2. First phase of glucose metabolism is glycolysis and occurs in the cytosol. In glycolysis glucose is broken down from a 6-c molecule to two 3-c molecules called pyruvate. The net output is 2 nadh and 2atp. Oxidation of pyruvate occurs in the mitochondrion and occur in two stages. First, the conversion of the 3-c pyruvate to the a 2-c molecule of acetyl coa, followed by the oxidation of acetyl coa to carbon dioxide through the citric acid cycle. The oxidation of pyruvate to acetyl coa is catalyzed by the enzyme, pyruvate. Acetyl coa can be then further broken down through the citric acid cycle, which is also located in the mitochondrion. Citric acid cycle is a series of 8 reactions which break down the 2-c acetyl coa to the 1-c molecule of co2, while at the same time generating 3 molecules of nadh, 1 molecule of.

Related Questions

Which of the following is not a net product of the citric acid cycle for each molecule of pyruvate generated in glycolysis?

Select one:

a. 1 ATP (GTP)

b. 1 acetyl coA

c. 3 NADH

d. 1 FADH2

Question 2

Which of the following is NOT an end product for an acetyl group that enters the citric acid cycle?

Select one:

a. ATP

b. NADH

c. FADH2

d. oxaloacetate

Question 3

Once they have been processed through the citric acid cycle, the acetyl-CoA molecules from a single glucose molecule produce:

Select one:

a. 2 ATP, 6 NADH, 4 CO₂.

b. 6 NADH, 6 GTP.

c. 6 FADH₂, 2 ATP, 6 CO₂.

d. 6 GTP, 6 FADH₂.

e. 4 CO₂, 6 FADH₂, 2 ATP.

Question 4

The products of the citric acid cycle breaking down 2 acetyl-CoA include 2 ATP (converted from GTP), 6 NADH and 2 FADH2.

Select one:

True

False

Match the following ATP yields to the following reactions.
2ATP
3ATP
6ATP
12ATP
18ATP
36ATP
44ATP

1.Glucose yields two pyruvate.
2.Pyruvate yields acetyl CoA.
2.Glucose yields two acetyl CoAs.
4.Acetyl CoA goes through one turn of the citric acid cycle.
5.Caproic acid (C6) is completely oxidized.
6.NADH + H+ is oxidized to NAD+
7.FADH2 is oxidized to FAD.

Carbohydrates are broken down into glucose monomer and dimers. Glucose is converted to pyruvate and then to acetyl CoA. Acetyl CoA enters the citric acid cycle and is broken down to CO2 and in the process produces NADH & FADH2, which is utilized in the generation of ATP via the electron transport chain. Why does the cell go through this elaborate pathway to convert glucose to carbon dioxide and water and in the process generate ATP? Why not use a simpler and shorter mechanism to breakdown glucose?

BIOCHEM 2EE3 Lecture Notes - Lecture 10: Thioester, Oxaloacetic Acid, Thiamine Pyrophosphate

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