BIOCHEM 2EE3 Lecture Notes - Lecture 4: Phagocytosis, Humoral Immunity, Antigen
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Gibbs free energy of activation (g ): equal to the di erence in free energy between the transition state and substrate (s) Gibbs free energy change ( g): the free energy di erence between (s) substrate and (p) product indicates if reaction is energetically favourable or not but doesn"t tell anything about rate of rxn rate of rxn government by g . Gibbs free energy equation: g = h - t s. Enzymes as catalysts hydrolysis of an ester by oh ion = enzyme catalysis. C=o bond substrate upon binding is pushed to t in order to be more complementary to the ts shape and not initial substrate shape. Antibody: a y shaped protein molecule produced by b-cells whose function is to recognize and bind to speci c antigens. Antigen: a substance that elicits an immune response (i. e. production of antibodies) Anatomical barriers - ex. skin, mucous membranes and stomach acid.