BIOCHEM 2EE3 Lecture 3: Module 2 video 1

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Strong link/bond analogous to a covalent bond (strong bond in a biological system) requires a lot of energy to break very stable. Weak link/bond analogous to a non-covalent bond a strong chain is linked to another strong chain by a very weak link. Does not require a lot of energy to break apart. the driving force of molecular interactions that occur within our cells. focus on how they pertain to protein-protein, protein-nucleic acid and nucleic-acid - nucleic acid interactions. Non-covalent interactio(cid:374)s do(cid:374)"t typi(cid:272)ally (cid:373)ake up macromolecules like this myoglobin protein depicted here (this honor is typically reserved for covalent bonds, which are very strong bonds, about 200 kj/mol). Non-covalent interactions are: individually very weak (only a few kj/mol) Weakness allows macromolecules to interact with one another very often in the cell as these interactions can be broken and re- formed multiple times in a cell (this is not done easily by strong covalent interactions).

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