ANTHROP 2U03 Lecture Notes - Lecture 10: Tuberculous Cervical Lymphadenitis, Social Forces, Sputum
6 Dec 2017
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Spreads via lymphatic and blood systems to other sites. Most people control initial infection by a cell-mediated immune response that prevents disease but can leave a residual population of viable mycobacteria. Between 5-10% of individuals who become infected subsequently develop clinical disease. Pi(cid:374)al lesio(cid:374)s a(cid:374)d kyphosis usually i(cid:374) lo(cid:449)e(cid:396) (cid:271)a(cid:272)k (cid:862)pott(cid:859)s disease(cid:863) No unequivocal evidence found in palaeolithic (i. e. before 10,000 years ago) Skeletal evidence for at least 6000 years (i. e. 3000 to 5000 bc) The genome sequences of m. tuberculosis and m. bovis are 99. 95% identical (although. North and south american sites with pre-columbian tuberculosis-like lesions in human remains. The (cid:862)(cid:272)lassi(cid:272)(cid:863) (cid:373)odel of tb e(cid:448)olutio(cid:374) is that: the bacterium is entirely clonal in structure (i. e. no recombination, that the lack of sequence diversity in m. tuberculosis. First written descriptions from sanskrit records (1500 700 y. a. ) The 18th century tb pandemic: a 300-year epidemic cycle. Mortality increased in countries with growing urban populations: industrialization. 20% of all deaths (england, japan, france)
