PSYC 342 Lecture Notes - Lecture 21: Neuroglycopenia, Leptin, Ghrelin
20 Apr 2016
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When bmi exceeds 30 they are obese debatable because of individual weight distribution etc. Psycho/behavioural and socio/cultural characteristics associated with obesity: high dietary restraint paired with overeating (yo-yo effect), availability of high fat and sugar food, energy expenditure (e. g. truck driver or office workers vs. farmers) Endocrine profile: high peripheral-central concentration of leptin but low central/peripheral leptin ratio (not enough leptin in the brain? dysregulation of leptin in the brain?) Take away: leptin dysregulation is characteristic of obesity. Endocrine profile: low levels of leptin/insulin, decreased ghrelin, hypoercortisolemia*, hypogonadism. Treatment: antidepression etc. then sometimes estrogens, gh anorexia cachexia (associated with a disease e. g. cancer) new treatment=ghrelin agonist that passes blood brain barrier. Model: how the brain demands energy from the body. Brain=2% of body mass but consumes 50% glucose (not fatty acids or amino acids) Astrocytes: manage glucose, responsible for absorbing glucose from circulation and giving it to themselves and the neurons energy on demand process.
