PSYC 318 Lecture Notes - Lecture 17: Donald O. Hebb, Nmda Receptor, Eyeblink Conditioning

• School: McGill University
• Department: Psychology
• Course: PSYC 318
• Professor: Jonathan Britt

Document Summary

Initial mechanisms for ltp and ltf show some differences at one point, but now words have been used for any broad long-term change in neurons: ltf in aplysia. Increase in synaptic strengths which is maintained: called long-term potentiation, esp. when maintained for a period of time. If you only give high frequency stimulation to just one input then the other input doesn"t show increase in synaptic strength: synapse specificity. Nmda current, there"s no increase in nmda current under ltp in most circumstances, you only see one in ampa current. Initial mechanism that doesn"t require protein synthesis and gene expression: making a tag or an independent form of short-term memory. Ltp: e-ltp doesn"t require proteins synthesis, l-ltp lasts longer, protein synthesis inhibitor after l-ltp it gets blocked very early afterwards, earlier than e-ltp is dependent on protein synthesis. If they don"t remember maze they don"t show that preference: a way of testing animal"s spatial memory.