PHGY 209 Lecture Notes - Lecture 32: Long Bone, Bilirubin, Yolk Sac
21 Jul 2016
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After that, it can not be differentiated from other rbc: red cell precursors differentiation o decrease in size stem cell is 18 micrometers and the reticulocyte is 7 micrometers o loss of nucleus o accumulation of hb, normal reticulocyte count <1% (reflects the amount of effective erythropoiesis in bone marrow), factors determining # of rbcs o o2 requirements o o2 availability, erythropoietin o a glycoprotein hormone/cytokine produced largely by the kidney o stimulus for its release is hypoxia low 02 levels (which may result in a decreased number of rbc or decreased availability of 02 to blood, or increased tissue demanding 02). o it has been purified, sequence, gene has been cloned, and epo has been produced by recombinant dna technology, to increase the production of rbc o the kidney will increase the release of erythropoietin, which will go into the plasma.
