PHGY 209 Lecture Notes - Lecture 18: Pernicious Anemia, Hypochromic Anemia, Microcytic Anemia

• School: McGill University
• Department: Physiology
• Course: PHGY 209
• Professor: John White

Document Summary

Usually failure to absorb vit b12 because its readily available in animal products (intrinsic factor deficiency pernicious anemia), and for folic acid usually dietary absence, overcooking vegetables: vitamin b12 is released in the stomach and it comes in contact with intrinsic factor (glycoprotein in gastic juice), forming complex if b12, it travels to small intestine where the absorption takes place. Abnormal hb structure sickle cell anemia mutation: acquired toxins, drugs, and antibodies iron o total amount in body 4g 65% hb, 30% stored, 5% myoglobin, 1% enz . daily intake is 15 20mg o requires 25mg fe/d for erythropoiesis, normal rbc destruction. Have important enzyme systems. o glycolytic enzymes generate energy o carbonic anhydrase co2 transport: hemorrhage loss of blood externally or internally (into tissues). 33% is hb, and the rest is composed of lipids, proteins, ions: what is hb? o polypeptide chain that is composed of 4 chains of aa.