PHGY 209 Lecture Notes - Lecture 11: Neutrophil Extracellular Traps, Innate Immune System, T Helper Cell
21 Feb 2018
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Document Summary
Immunology is where the evolutionists and theologists meet. Bubble boy (no thymus, no bone marrow) Upon the breach of the body coverings, the innate immune response begins: The macrophage phagocytoses an immunogen which allows it to set up a signal called mdncf (macrophage derived neutrophil chemotactic factor). The mdncf is a molecule derived from the macrophage which chemotactically attracts neutrophils to the site of infection. The neutrophil will roll into the site through a process called diapedesis where it will explode to release its contents. The result of neutrophil death in the process of killing bacteria: helps in host defense, the production of pus (a mixture of dead bacteria and dead neutrophils) Indicator of an innate immune response = inflammation: neutrophil extracellular traps (nets) are made of processed chromatin bound to granular and selected cytoplasmic proteins. Nets are released by white blood cells called neutrophils, maybe as a last resort, to control microbial infections.
