PHGY 209 Lecture Notes - Lecture 6: Flavor, Brainstem, Neuromodulation
12 Jan 2018
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Both receptors only respond to glutamate neurotransmitter which is an excitatory potential & both coactivator increase a synapse"s strength. The open pore is highly permeable to ca2+ as well as monovalent cations. At -70 mv almost all the synaptic current at an excitatory glutamate synapse is carried by na+ through ampa receptors; however, if the postsynaptic membrane is depolarized, a substantial. Nmda: glutamate binds to its receptor= nothing happens because the. So now that the mg2+ is out glutamate can cause the nmda receptor to function and open the ion channel which allows ca+ to flow into the neuron. Synaptic plasticity: synapses can get stronger important because it"s the underlying physiology for how we learn. High concentrations of glutamate are toxic to neurons. Can measure epsp in the synapses with electrodes. Long-term potentiation (ltp) is a model of synaptic plasticity. Initial contribution to epsp comes from activation of.
