PHGY 209 Lecture Notes - Lecture 10: Liver Disease, Kidney Disease, Antibody
30 Oct 2016
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Document Summary
Factors in trans capillary dynamics: hydrostatic pressure, c. o. p, capillary permeability, lymphatic drainage. Edema: accumulation of excess fluid in the interstitial spaces. Swelling due to injury: isf compartment becomes larger than the plasma compartment, conditions leading to edema, increase in hydrostatic pressure. Instead of 35mmhg entering capillaries, its 55mmhg. Instead of 15mmhg leaving capillaries, its 25mmhg: they are much higher pressures. The c. o. p hasn"t changed: net filtration: 30mmhg (55, net absorption: 0 mmhg (25, decrease in plasma protein (c. o. p) Instead of 25mmhg c. o. p, its 15: net filtration: 20mmhg, net absorption is 0mmhg. Can be caused by: liver disease (failure to synthesize protein, kidney disease (very permeable, filtered out, severe protein malnutrition, increase in capillary permeability. Plasma protein can escape into isf if increased permeability causing an oncotic effect. C. o. p decreases (25 to 20: 5mmhg has entered isf, obstruction of lymphatic drainage. Elephantiasis: legs are swollen, infiltration of a parasite (filarial nematode) Accumulate in lymph nodes and block drainage from the legs.
