PHAR 562 Lecture Notes - Lecture 18: Conditioned Place Preference, Brenda Milner, Electrical Brain Stimulation
13 Nov 2017
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Background reading: rang and dale"s pharmacology 8th edition, chapter 48 and 49, except sections on psychomimetic drugs and harmful effects of smoking. Today we will talk about animal models related to addiction. None of them are sufficient to fully model addiction that we would see in humans. Topic 1: a brief history of drug abuse. Initially thought to be a gift from the sun god. Popularised in europe: nerve tonics widely sold in 19th century, blurred the distinction between recreation drugs and those that fortified the body. Opium wars between british empire and china. American civil war important bc opioid analgesics were widely used at this time. Invention of hypodermic needles facilitate drug abuse. To combat dependence on morphine creation of heroin: tried to help the soldier"s disease . One definition of drug addiction: chronic neurobiological disease, genetic, psychosocial and environmental factors, behaviours include one or more of the following.
