PHAR 562 Lecture Notes - Lecture 2: Temporal Lobe Epilepsy, Neural Development, Speech-Language Pathology
8 Sep 2017
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Document Summary
Cns disorders: multifactorial (genetic, epigenetic, environment, neuronal signaling, disease is managed by treating the symptom, no cures available, (cid:862)magi(cid:272) (cid:271)ullet(cid:863) strategy is i(cid:374)appropriate, future success will require better, diagnostic criteria, fuller understanding of pathology. Rett"s sy(cid:374)dro(cid:373)e: neurological disorder affecting mostly girls due to a mutation in mepc2 on the x chromosome. Individuals are born normal but see a rapid decline in behaviour and develop cv/gi problems and seizures lose nervous system function by age 15: no cure treatment is only symptomatic. Mood disorders: major depression and bipolar disorder, drug therapies started in the 50s when it was discovered that catecholaine and serotonin levels were different in depressed patients: ssris, snris, tcas, and maois. Pain: classification of pain, nociceptive pain associated with tissue damage. Inflammatory pain associated with tissue damage and infiltration of immune cells: pathological pain due to damage (neuropathic) or dysfunction (e. g. in fibromyalgia, many drugs used for treatment: opioids, nsaids, ads and anticonvulsants, cannabinoids.
