PHAR 303 Lecture Notes - Lecture 12: Sideroblastic Anemia, Vitamin B12 Deficiency, Iron-Deficiency Anemia

• School: McGill University
• Department: Pharmacology and Therapeutics
• Course: PHAR 303
• Professor: Bernard Robaire

Document Summary

Lecture 12: toxicants targeting the blood or immune system. Supply of o2: production of vital growth factors (interleukins, colony-stimulating factors, clearance of toxins, drugs, and metabolites. Occurs in the axial skeleton, humerus & femur. Rbc, granulocytes, platelets produced at rate of 1-3 million/sec: by having such high division rates, they are a prime target for toxicants. The neutrophils are the most numerous ones - phagocytosis and inflammation. The monocytes are macrophage precursors; they are also phagocytic. Delivery of oxygen to tissues --> hypoxia (erythrocytes) Coagulation --> hemorrhage (damages on platelets, proteins from liver & vascular endothelial cells) Secondary toxicity: toxicity as a consequence of other tissue injuries. Phar 303: targeting erythrocytes, the toxicant can either affect blood cell production or the function of survival, anemia: decrease in red blood cell numbers. Alterations in rbc production: decreased hemoglobin synthesis, change in globin chains, decreased heme synthesis. Defects in hemoglobin a synthesis: change in globin chains.