PHAR 303 Lecture Notes - Lecture 6: Cardiovascular Disease, Nerve Agent, Hemoglobin
9 Aug 2019
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Interesting fact: banned nerve agent killed kim jong nam within 20 minutes. It is a liquid that is quickly absorbed through the skin. Chemicals that can produce side effects on the heart: antibiotics, bacterial lps sepsis, catecholamines cardiomyopathy, cns drugs antipsychotics, antidepressants, simulants, anticonvulsants, antineoplastic agents, passive smoking, steroids, carbon monoxide. The cardiovascular disease triad: brain and cerebral circulation (cerebrovascular disease, heart and coronary circulation (coronary heart disease, lower limbs (peripheral vascular disease) Structures of the heart: superior vena cava, aorta, pulmonary artery, mitral valve, tricuspid valve, chordae tendinae, interventricular septum. Electrical system of the heart: sa node, av node, bundle of his, purkinje fibers (conduction myofibers, left bundle branch, right bundle branch. Sa node is the pacemaker of the heart. It depolarizes with the greatest frequency and most rapidly. However, if something goes wrong with the sa node, there is a backup system. Av node can also depolarize, but more slowly.
