PHAR 303 Lecture Notes - Lecture 4: Toxicokinetics, Hepatotoxicity, Stratum Corneum

• School: McGill University
• Department: Pharmacology and Therapeutics
• Course: PHAR 303
• Professor: Bernard Robaire

Document Summary

Toxicant will be delivered to the body (toxicokinetics) and will interact with target molecules target molecules (toxicodynamics: toxicokinetics is how the molecules get to their endpoints. This includes how it"s handled, what it does: within this, we worry about absorption, metabolism, metabolism, and elimination. Toxicokinetics; the modeling and mathematical description of the time course of the disposition of toxicants. The exposure can be through skin, gi tract, respiratory tract, injections/bites, placenta. The toxicant must be able to get in to be delivered to the target molecule. There are reabsorption processes which can give an opportunity for elimination. Toxication: if a metabolite is changed to be more toxic than the original chemical. Detoxification: if a toxicant is metabolized and becomes less toxic. The chemical must get through a membrane to have an effect: the membranes have lots of lipids (cholesterol, 7 - delivery of toxicants phospholipids), so chemicals can pass through membranes much more easily if they are lipid soluble.