PHAR 301 Lecture Notes - Lecture 14: Desloratadine, Intraperitoneal Injection, Chemical Synapse

• School: McGill University
• Department: Pharmacology and Therapeutics
• Course: PHAR 301
• Professor: Barbara Hales

Document Summary

Phar 301 lecture 14: clarke (short notes) Read entire chp 11 as revision if you need it but only certain pages are directly relevant to sympatomimetics. Read only p. 154, 157-161 and disregard pharmacovigilance section (p. 160-161) **drugs to know by name: phenylpropanolamine (ppa), phenylephrine, pseudoephedrine (sudafed), Amphetamine, diphenhydramine (1st gen sedating histamine), terfenadine (non-sedating antihistamine) Principles covered in lecture: how drugs can fail (and hopefully be replaced) phenylephrine, pseudoephedrine, ppa, terfenadine, withdrawal rebound, surmountable vs insurmountable antagonism, spare receptors, beneficial side effects seen in antihistamine drugs. Three main approaches for a congested nose: sympathomimetic drugs: increase (or mimic) in na transmission, antihistamine h1 receptor antagonists (remember that h2rs are found in the gut) Ineffective for clearing the nose during a cold. In the beginning, amphetamine was not thought to be addictive. Oral and topical decongestants: nasal decongestants are for symptomatic imitating the sns, all have a similar chemistry to adrenaline.