PHAR 300 Lecture Notes - Lecture 17: Seminiferous Tubule, Male Contraceptive, Dna-Binding Domain
26 Mar 2020
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Document Summary
It is a challenge to develop male contraceptives. Testis is located in the scrotum, seminiferous tubules are metres long (male sperm cells develop in the testis, through the epididymis, up the tubule to hopefully fertilize an egg) Need to end up with mature haploid spermatozoa. This process is highly organized and takes place in the testis. Duration of spermatogenesis is 64 days for humans it is species-specific: there are differences in sperm production within species as well, e. g. testis is magnitudes higher for boar than humans, highly specialized. Seminiferous tubule: early stages of germ cells line the outside of the tubules, but as they progress to spermatozoa, they migrate up so that the more mature germ cells are outside. Testosterone biosynthesis: steroidogenesis is the same, making precursors of testosterone in response to. Testosterone + aromatase estradiol (adding cyclic component) Testosterone + 5 -reductase dihydrotestosterone (getting rid of the double bond)
