PHAR 300 Lecture 12: Lecture 12
10 Jan 2019
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Document Summary
Reasonable evidence against certain types of pain chemotherapy nausea and vomiting. Family act on cb receptors: epilepsy, etc. (see slides, cb1, cb2, these are endocannabinoid receptors with natural ligands: Highest concentration in brain and spinal cord. Endogenous compounds that are natural agonists: basic point: receptors spread in many locations, widespread, arachidonoylethanolamide. Synthesized in post-synaptic neuron (aea or 2ag) Releases endogenous endocannabinoids to interact with presynaptic to repress neurotransmitter (release in presynaptic neurons. End result: decrease in calcium entrance and increase of k (hyperpolarize) Can be absorbed through skin (but not a common way to do because not goo effect) Apparent volume of distribution: extracellular body water and fat. Metabolism: mostly in liver, secretion in hair, saliva, sweat, excrete in bile and urine. Main risks also similar: heart attacks. Mcgill university phar 300 prof. e. zorchyta, prof. b. hales: stokes, cancers. We don"t have long-term data and don"t know long-term effects. Smoke from any biomass burning is carcinogenic.
