PARA 438 Lecture Notes - Lecture 12: Rudolf Virchow, Louis Pasteur, Nitric Oxide
25 Oct 2018
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Disease characterized by: heat, redness, edema, pain by cornelius celsus. Rudolf virchow: + another characteristic: leading to loss of function. Louis pasteur: germ theory of disease (disease started bc of microorganisms) Paul ehrlich: soluble things in bld would induce inflammation --- humoral theory. Both em and pe are right --->nobel prize. Physiological reaction of organism: infection, trauma, surgery, burn, tissue infraction, cancer objectives: to eliminate stimulus; promote tissue repair + wound healing; establish memory. Aim for training: need inflammation to bring back to improve performance. Histamine (allergic inflammation), serotonin [preformed] prostaglandin (lipid), chemokine (protein), ros, nitric oxide. 1st immune cell to arrive eliminate foreign microorganisms (phagocyte) Para 438 page 1 eliminate foreign microorganisms (phagocyte) Extracellular: neutrophil extracellular traps (nets) -- kill pathogen outside cell without phagocyte. Eliminate injurious agents (microorganism, things from own cell) Inflammatory cell has d6, dark -- chemokine r that has no signal transduction (nothing downstream)
