PARA 438 Lecture Notes - Lecture 16: Pumpkin Seed Oil, Immunoglobulin Class Switching, Cod Liver Oil
25 Oct 2018
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Obesity is almost the same compare to us. Obese individual: lower lymphocyte capacity; lower nkc activity. Adipose: similar to macrophage, can be seen as immune cell. Adipose & macrophage things in common: lipid storage + cytokine secretion. Va: innate (a barrier)+ acquired immune system - correct epithelial cell functioning; deficiency: stop secreting mucus; maintain number (of lymphocyte, nkc, neutrophil, macrophage, dendritic); essential for hematopoiesis; formation of tight junction (make it impermeable) Source: cod liver oil, liver, egg, carrot, oranges, pumpkin seed oil. Deficiency: reduce number of complement protein, nk, tc; increase ifn (activate macrophage, express mhc, ig class switching) Overdosing of sugar: immune-suppression: reduce leukocyte ability to kill germs; tarts <30 min. Excess alcohol: can produce nutritional deficiency; reduce leukocyte ability to kill; inhibit killer cell on cancer, lessen ability of macrophage (produce tnf) Food allergen (4% of individual): generated after several encounters with food allergens, the wall is damaged, so invader gets into the bld stream.
