PARA 438 Lecture Notes - Lecture 3: Extracellular Fluid, Dendritic Cell, Signal Transduction

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Non specific host defenses exist prior to exposure to ag and involve: O2 is toxic for bacteria (anaerobes) (to kill bacteria) These 4 are cells that actually involved in innate immunity. Cytokine: the fuel for cell to get into fight sits between innate immunity and adaptive immunity. By phagocytosis; ingest a lot extracellular fluid + its contents. To activate t cells / activate ag r of t cells. Found in fruit fly, mutation in protein toll, made flies susceptible to infection. Toll: a trans-mem signal r protein of leukocyte involved in innate immunity. Exterior region: lrr- leucine-rich repeats; some are stink outside and some inside. Some tlr located on surface of dendritic cell, macrophages --->able to detect extracellular pathogen molecules. Others are located: intracellularly in wall of endosomes. Detect bacterial dna, that are accessible only after microbe has been broken down. Tlr 7: is it on the surface of mem / in the endosome? (i determine)

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