PARA 438 Lecture Notes - Lecture 9: Monokine, Mast Cell, Pleiotropy
25 Oct 2018
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Sensor cell - loss of homeostasis + communicate to effector cell. Effector cell - can be sensor cell (autocrine) Embryonic development: cell differentiation; disease pathogenesis; non- specific / specific; change cognitive function; aging -degenerative progress. Definition of cytokine: soluble factor to cell communication. Rbc can"t produce nor respond to a cytokine. No nucleus to respond + have cascade for gene expression. Neutrophil can release cytokines and have the above effects to the body. Able to have proliferation and differentiation of t cells. Pleiotropy : 1 cytokine can induce diff reaction / do diff things. Redundancy: more than 1 cytokine can trigger proliferation of target cell. Cascade induction: 1 cytokine released from 1 cell and induce another cytokine production from other cells, and even go back to the first cell. 1 single molecule have multiple + diverse activities (ex. Il1 induction of body t, liver protei(cid:374) s(cid:455)(cid:374) ) Present homology + promiscuity in reciprocal r system.
